芳香烃受体
交易激励
白藜芦醇
化学
药理学
孕烷X受体
体内
生物化学
生物
核受体
转录因子
基因
生物技术
作者
Robert F. Casper,Monique Quesne,Ian Rogers,Takuhiko Shirota,André Jolivet,Edwin Milgröm,Jean‐François Savouret
出处
期刊:PubMed
日期:1999-10-01
卷期号:56 (4): 784-90
被引量:110
摘要
Aryl hydrocarbon receptor (AhR) ligands such as dioxin and benzo[a]pyrene are environmental contaminants with many adverse health effects, including immunosuppression, carcinogenesis, and endothelial cell damage. We show here that a wine component, resveratrol (3,5,4'-trihydroxystilbene), is a competitive antagonist of dioxin and other AhR ligands. Resveratrol promotes AhR translocation to the nucleus and binding to DNA at dioxin-responsive elements but subsequent transactivation does not take place. Resveratrol inhibits the transactivation of several dioxin-inducible genes including cytochrome P-450 1A1 and interleukin-1beta, both ex vivo and in vivo. Resveratrol has adequate potency and nontoxicity to warrant clinical testing as a prophylactic agent against aryl hydrocarbon-induced pathology.
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