抗菌剂
抗菌肽
细胞通透性
生物活性
核酸
药物输送
膜透性
细胞内
细胞
化学
生物
微生物学
膜
生物化学
体外
有机化学
作者
Idris Zubairu Sadiq,Aliyu Muhammad,Sanusi Bello Mada,Bashiru Ibrahim,Umar Aliyu Umar
出处
期刊:Tissue barriers
[Informa]
日期:2021-10-25
卷期号:10 (3)
被引量:5
标识
DOI:10.1080/21688370.2021.1995285
摘要
Selective permeability of biological membranes represents a significant barrier to the delivery of therapeutic substances into both microorganisms and mammalian cells, restricting the access of drugs into intracellular pathogens. Cell-penetrating peptides usually 5–30 amino acids with the characteristic ability to penetrate biological membranes have emerged as promising antimicrobial agents for treating infections as well as an effective delivery modality for biological conjugates such as nucleic acids, drugs, vaccines, nanoparticles, and therapeutic antibodies. However, several factors such as antimicrobial resistance and poor drug delivery of the existing medications justify the urgent need for developing a new class of antimicrobials. Herein, we review cell-penetrating peptides (CPPs) used to treat microbial infections. Although these peptides are biologically active for infections, effective transduction into membranes and cargo transport, serum stability, and half-life must be improved for optimum functions and development of next-generation antimicrobial agents.
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