蛋白酵素
生物
毒力
微生物学
白色念珠菌
蛋白酶
先天免疫系统
免疫系统
补体系统
分泌物
酶
基因
生物化学
免疫学
作者
Monika Staniszewska,Małgorzata Bondaryk,Zbigniew Ochal
出处
期刊:Current Protein & Peptide Science
[Bentham Science]
日期:2017-08-16
卷期号:18 (10)
被引量:30
标识
DOI:10.2174/1389203717666160809155749
摘要
Candida species are the major opportunistic human pathogens accounting for 70-90% of all invasive fungal infections. Candida spp, especially C. albicans, are able to produce and secrete hydrolytic enzymes, particularly aspartic proteases (Saps). These enzymes production is an evolutionary adaptation of pathogens to utilize nutrients and survive in host. Sap1-10 are believed to contribute to the adhesion and invasion of host tissues through the degradation of cell surface structures. Aspartic proteases control several steps in innate immune evasion and they degrade proteins related to immunological defense (antibodies, complement and cytokines), allowing the fungus to escape from the first line of host defense. The existing ways to identify potential drug targets rely on specific subset like virulence genes, transcriptional and stress response factors. Candida virulence factors like Sap isoenzymes can be pivotal targets for drug development. The identification of mechanism of a non-canonical inflammasome exerted by Saps could open novel therapeutic strategies to dampen hyperinflammatory response in candidiasis.
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