Inside Front Cover: Protein amyloid aggregate: Structure and function

Amyloid protein aggregation represents a crucial biological process with notable physiological relevance and significant implications in disease pathology. These amyloid aggregates, characterized by their unique structures, gain a variety of biological functions. In this review (e333), Liu and his colleagues delve into the mechanisms that dictate the conformational transitions and assembly of amyloid proteins into aggregates. They illuminate the intricate structure-function relationship of these amyloid aggregates, enhancing our comprehension of their role and impact in health and disease contexts.