基底外侧杏仁核
扁桃形结构
心理学
神经科学
移情
光遗传学
扣带回前部
海马结构
脑功能偏侧化
认知
精神科
作者
Seok‐Jin Kim,Minsoo Kim,Jong Hwan Baek,Charles Latchoumane,Gireesh Gangadharan,Yongwoo Yoon,Duk‐Soo Kim,Jin Hyung Lee,Hee‐Sup Shin
出处
期刊:Neuron
[Elsevier]
日期:2023-02-01
卷期号:111 (3): 418-429.e4
被引量:8
标识
DOI:10.1016/j.neuron.2022.11.001
摘要
Observational fear, a form of emotional contagion, is thought to be a basic form of affective empathy. However, the neural process engaged at the specific moment when socially acquired information provokes an emotional response remains elusive. Here, we show that reciprocal projections between the anterior cingulate cortex (ACC) and basolateral amygdala (BLA) in the right hemisphere are essential for observational fear, and 5-7 Hz neural oscillations were selectively increased in those areas at the onset of observational freezing. A closed-loop disruption demonstrated the causal relationship between 5-7 Hz oscillations in the cingulo-amygdala circuit and observational fear responses. The increase/decrease in theta power induced by optogenetic manipulation of the hippocampal theta rhythm bi-directionally modulated observational fear. Together, these results indicate that hippocampus-dependent 5-7 Hz oscillations in the cingulo-amygdala circuit in the right hemisphere are the essential component of the cognitive process that drives empathic fear, but not freezing, in general.
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