毛螺菌科
肠道菌群
丙二醛
厚壁菌
超氧化物歧化酶
谷胱甘肽过氧化物酶
链脲佐菌素
内科学
过氧化氢酶
糖尿病
2型糖尿病
内分泌学
氧化应激
2型糖尿病
化学
生物
生物化学
医学
16S核糖体RNA
基因
作者
Nannan Liu,Mengyin Chen,Jiazheng Song,Yuanyuan Zhao,Pin Gong,Xuefeng Chen
出处
期刊:Molecules
[MDPI AG]
日期:2022-09-16
卷期号:27 (18): 6061-6061
被引量:3
标识
DOI:10.3390/molecules27186061
摘要
In previous studies, Auriculariaauricula polysaccharides (AAP) has been found to improve type 2 diabetes mellitus, but its mechanism remains unclear. In this study, we sought to demonstrate that AAP achieves remission by altering the gut microbiota in mice with type 2 diabetes. We successfully constructed a type 2 diabetes mellitus (T2DM) model induced by a high-fat diet (HFD) combined with streptozotocin (STZ), following which fasting blood glucose (FBG) levels and oral glucose tolerance test (OTGG) were observed to decrease significantly after 5 weeks of AAP intervention. Furthermore, AAP enhanced the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA) to alleviate the oxidative stress injury. AAP-M (200 mg/kg/d) displayed the best improvement effect. Moreover, 16S rRNA results showed that AAP decreased the abundance of Firmicutes and increased that of Bacteroidetes. The abundance of beneficial genera such as Faecalibaculum, Dubosiella, Alloprevotella, and those belonging to the family Lachnospiraceae was increased due to the intake of AAP. AAP could reduced the abundance of Desulfovibrio, Enterorhabdus, and Helicobacter. In all, these results suggest that AAP can improve the disorders of glucose and lipid metabolism by regulating the structure of the gut microbiota.
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