A Knowledge-based and Data-driven Approach for Predicting Acute Kidney Injury in Patients with Heart Failure*

It has great potential to integrate medical knowledge and electronic health record data for diagnosis prediction. However, present studies only utilized information from knowledge graphs, omitting potentially significant global graph structural features. In this study, we proposed a knowledge and data integrating modeling approach to reconstruct patient electronic health record data with graph structure and use medical knowledge as internal information of patient data to build a risk prediction model for acute kidney injury in patients with heart failure based on graph neural networks. Experimental results based on the MIMIC III data showed that the method proposed was superior to other baseline models in predicting the risk of acute kidney injury in heart failure patients, with an accuracy of 0.725 and an F1 score of 0.755. This study provides a novel approach to the disease risk prediction models that integrates medical knowledge and data.