淋巴系统
组织工程
淋巴管内皮
再生(生物学)
血管
医学
芯片上器官
电流(流体)
血管网
神经科学
病理
生物
解剖
生物医学工程
微流控
工程类
细胞生物学
内科学
纳米技术
材料科学
电气工程
作者
Aldina Crnic,Sabrina Rohringer,Tatiana Tyschuk,Wolfgang Holnthoner
标识
DOI:10.1016/j.atherosclerosis.2024.117458
摘要
The human vasculature plays a crucial role in the blood supply of nearly all organs as well as the drainage of the interstitial fluid. Consequently, if these physiological systems go awry, pathological changes might occur. Hence, the regeneration of existing vessels, as well as approaches to engineer artificial blood and lymphatic structures represent current challenges within the field of vascular research. In this review we provide an overview of both, the vascular blood circulation and the long-time neglected but equally important lymphatic system, with regard to their organotypic vasculature. We summarize the current knowledge within the field of vascular tissue engineering focusing on the design of co-culture systems, thereby mainly discussing suitable cell types, scaffold design and disease models. This review will mainly focus on addressing those subjects concerning atherosclerosis. Moreover, current technological approaches such as vascular organ-on-a-chip models and microfluidic devices will be discussed.
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