化学
异三聚体G蛋白
三螺旋
生物物理学
分类
翻译后修饰
生物化学
立体化学
信号转导
G蛋白
算法
酶
计算机科学
生物
作者
Valdrin Islami,Philipp Bittner,Tomas Fiala,Nina B. Hentzen,Renato Zenobi,Helma Wennemers
摘要
Nature uses elaborate methods to control protein assembly, including that of heterotrimeric collagen. Here, we established design principles for the composition and register-selective assembly of synthetic collagen heterotrimers. The assembly code enabled the self-sorting of eight different strands into three─out of 512 possible─triple helices via complementary (4S)-aminoproline and aspartate residues. Native ESI-MS corroborated the specific assembly into coexisting heterotrimers.
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