Aspergillus-Induced Cardiac Injury Modeling and Preventive Strategy Screening via a Universal Precise Cardiomyocyte-Based Electrophysiological Biosensing Platform

. Acute exposure to 250 nM GT significantly increased the firing rate of cardiomyocytes within 8 h, while prolonged exposure progressively reduced the signal amplitude. Skullcapflavone II (SF2) can effectively protect against GT-induced cardiomyocyte damage by maintaining the electrophysiological signal stability. This self-developed platform provides a universal and precise tool to investigate the pathophysiology of Aspergillus-induced cardiac injury and to assess protective strategies through real-time electrophysiological monitoring.