A Mitochondria‐Targeted Nanozyme Platform for Multi‐Pathway Tumor Therapy via Ferroptosis and Cuproptosis Regulation

S-TPP/FA nanoplatform effectively delivered copper ions to mitochondria and iron ions to tumor cells, modulating key ferroptosis- and cuproptosis-related markers, such as GPX4, GSH, FDX-1, and HSP70. The platform synergistically combined photothermal effects with multi-pathway cell death mechanisms, achieving significant anti-tumor efficacy in vitro and in vivo. This study underscores the therapeutic potential of synchronously delivering copper and iron ions and highlights mitochondria-targeted strategies in advancing multi-modal cancer therapies.