2D Cobalt Oxyhydroxide Nanozymes Inhibit Inflammation by Targeting the NLRP3 Inflammasome (Adv. Funct. Mater. 27/2023)

Inflammatory Bowel Disease Relief In article number 2214693, Yunjiao Zhang and co-workers demonstrate 2D cobalt oxyhydroxide nanosheets (Co NSs) with excellent multienzyme-like activity as potential inhibitors of NLRP3 inflammasome and pyroptosis. Owing to the robust reactive oxygen species scavenging and oligomerization inhibiting ability, Co NSs block the assembly and activation of NLRP3 inflammasome, thereby exhibiting anti-inflammation effect in colitis.