利拉鲁肽
医学
药方
小儿内分泌
肥胖
糖尿病
内分泌系统
儿童肥胖
2型糖尿病
胰高血糖素样肽-1
重症监护医学
内科学
内分泌学
家庭医学
药理学
激素
超重
作者
Evgenia Gourgari,Lina Huerta‐Saenz,Ksenia Tonyushkina,Elizabeth Rosolowsky,Ines Guttmann‐Bauman
摘要
Glucagon-like peptide-1 receptor agonists (GLP-1RA) have been widely used in adults with Type 2 diabetes (T2D) and obesity. We sought to evaluate the experience of pediatric endocrinology providers with GLP-1RA and factors that guide them on whether and how to prescribe these medications.We surveyed the members of the Pediatric Endocrine Society regarding the use of GLP-1RA in their practice.The respondents (n = 102) were predominantly from academic centers (84%) and 75%reported using GLP-1RA in pediatric patients, mostly to treat T2D and obesity. Patient tolerance for the medication was reported to be the driving factor determining the duration of treatment. Gastrointestinal side effects were observed more commonly than local reactions or elevation of pancreatic enzymes. Lack of clinical experience was reported to be a major barrier for prescribing GLP-1RA, particularly among those with more than 5 years of clinical experience. Finally, liraglutide was used more often (93%) than other GLP-1RA.The use of GLP-1RA has increased in pediatric patients. Recent Food and Drug Administration approval of liraglutide for pediatric obesity will likely further increase its prescription rate. Providers should be vigilant about side effects and adjust the doses of GLP-1RA accordingly. More efforts should be made by professional societies to educate pediatric endocrinology providers about the proper use of GLP-1RA and enhance their confidence in prescribing these medications.
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