化学
催化作用
亲核细胞
分子间力
药物化学
戒指(化学)
氧化磷酸化
甲烷氧化偶联
氧化加成
亲核加成
原子经济
立体化学
分子
有机化学
生物化学
作者
Shi‐Yi Zhuang,Yong‐Xing Tang,Xiang‐Long Chen,Yan‐Dong Wu,An‐Xin Wu
标识
DOI:10.1021/acs.joc.1c02204
摘要
A copper-catalyzed oxidative C(sp3)-H/C(sp3)-H cross-coupling reaction of methyl ketones and 3-methylbenzo[c]isoxazoles has been developed for the direct synthesis of 3-oxoindolin-2-ylidene derivatives. This process involves an intermolecular nucleophilic addition/ring-opening/aza-Michael addition cascade, providing indigoid analogues with high atom economy and as single isomers exclusively under mild conditions.
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