静电纺丝
双氯芬酸钠
溶解度
差示扫描量热法
结晶度
溶解
化学工程
纳米纤维
环糊精
扫描电子显微镜
材料科学
聚合物
双氯芬酸
色谱法
化学
纳米技术
有机化学
复合材料
工程类
物理
热力学
生物化学
作者
Attila Balogh,Tímea Horváthová,Zoltán Fülöp,Þorsteinn Loftsson,A. Harasztos,György Marosi,Zsombor Kristóf Nagy
标识
DOI:10.1016/j.jddst.2015.02.003
摘要
Electrospinning, electroblowing and freeze-drying were investigated to prepare fast dissolving cyclodextrin-based drug-loaded solid complexes. Combining the huge surface area of fibrous mats with the capabilities of cyclodextrins to prepare a reconstitution injection was tested to overcome the instability of liquid-based products. Diclofenac sodium was used as drug with limited water solubility and 2-hydroxypropyl-β-cyclodextrin (HPβCD) as carrier and solubilizer. The applied composition of the complex was determined based on phase solubility measurements. In order to resolve the frequent unavoidable interruption of the fiber formation during electrospinning from the HPβCD solution, high-speed blowing air was coupled with the electrostatic force (electroblowing) to draw polymer-free HPβCD fibers steadily, moreover, at increased flow rates. According to the scanning electron microscopic images, X-ray diffraction, differential scanning calorimetry no traces of crystallinity of the drug were detectable in the fibers as opposed to the freeze-dried product. Reconstitution tests of the fibers showed fast dissolution obtaining clear solutions equivalent to a marketed liquid-based bolus injection. The results demonstrate the first time the viability of electroblowing for preparing drug delivery systems.
科研通智能强力驱动
Strongly Powered by AbleSci AI