斯达
JAK-STAT信号通路
肾素-血管紧张素系统
血管紧张素II
医学
信号转导
癌症研究
内科学
生物
内分泌学
血压
细胞生物学
车站3
酪氨酸激酶
作者
Ryousuke Satou,Romer A. Gonzalez‐Villalobos
出处
期刊:JAK-STAT
[Informa]
日期:2012-10-01
卷期号:1 (4): 250-256
被引量:35
摘要
The renin-angiotensin system (RAS) plays important roles in blood pressure control and tissue disease. An inappropriate local angiotensin II elevation in the kidneys leads to the development of hypertension, tissue damage and chronic injury. Studies have demonstrated that the JAK-STAT pathway mediates angiotensin II-triggered gene transcription. The JAK-STAT pathway in turn, acting as an amplifying system, contributes to further intrarenal RAS activation. These observations prompt the suggestion that the JAK-STAT pathway may be of importance in elucidating the mechanisms RAS-associated tissue injury. Accordingly, this review provides a brief overview of the interactions between the JAK-STAT pathway and the RAS, specifically the RAS expressed in the kidneys.
科研通智能强力驱动
Strongly Powered by AbleSci AI