[Time course of changes in functional visual acuity and ocular wavefront aberration after instillation of ofloxacin gel-forming ophthalmic solution].

To investigate the influence of ofloxacin gel-forming ophthalmic solution on functional visual acuity (FVA) and ocular wavefront aberration.In the right eyes of 22 normal volunteers, FVA and ocular wavefront aberration were measured before and 1, 5, 10, 15, 30 minutes after the instillation of ofloxacin gel-forming ophthalmic solution (Gel group). Similar measurements were repeated after instillation of ofloxacin ophthalmic solution (Solution group) and ofloxacin ophthalmic ointment (Ointment group). The obtained data were compared among the three groups.Although no significant changes in FVA and total ocular higher-order aberrations (HOAs) were observed in the Solution group, FVA and HOAs significantly deteriorated in the Gel group and Ointment group at 1 minute after instillation. These changes gradually returned to the baseline levels. These changes were remarkable in the Ointment group. FVA deteriorated significantly in the Ointment group as compared with the Gel group up to 5 minutes after instillation (p<0.0167).Instillation of ofloxacin gel-forming ophthalmic solution significantly decreases FVA and increases HOAs, but these changes are less and shorter than the ofloxacin ophthalmic ointment.