Magnetic Resonance Elastography of the Mouse Brain In Vivo

In the current study we apply the magnetic resonance elastography (MRE) technique to estimate the dynamic shear modulus of mouse brain tissue in vivo. The frequency used (1200 Hz) is well above those reported previously [1]. Estimates of dynamic shear modulus range from 12,600–14,800 N/m2 at 1200 Hz. These data are strictly relevant only to small oscillations at this specific frequency, but these values are obtained at high frequencies (and thus high deformation rates) and non-invasively throughout the brain. These data complement measurements of nonlinear viscoelastic properties obtained by others at slower rates, either ex vivo or invasively.