细菌
抗菌活性
金黄色葡萄球菌
微生物学
大肠杆菌
化学
抗生素
达托霉素
组合化学
生物
万古霉素
生物化学
遗传学
基因
作者
Jingyang Shan,Xiao Li,Kangkang Yang,Weijun Xiu,Qirui Wen,Yuqian Zhang,Lihui Yuwen,Lixing Weng,Zhaogang Teng,Lianhui Wang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2019-11-07
卷期号:13 (12): 13797-13808
被引量:192
标识
DOI:10.1021/acsnano.9b03868
摘要
Antibacterial agents with high antibacterial efficiency and bacteria-binding capability are highly desirable. Herein, we describe the successful preparation of Cu2WS4 nanocrystals (CWS NCs) with excellent antibacterial activity. CWS NCs with small size (∼20 nm) achieve more than 5 log (>99.999%) inactivation efficiency of both Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) at low concentration (<2 μg mL–1) with or without ambient light, which is much better than most of the reported antibacterial nanomaterials (including Ag, TiO2, etc.) and even better than the widely used antibiotics (vancomycin and daptomycin). Antibacterial mechanism study showed that CWS NCs have both enzyme-like (oxidase and peroxidase) properties and selective bacteria-binding ability, which greatly facilitate the production of reactive oxygen species to kill bacteria. Animal experiments further indicated that CWS NCs can effectively treat wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). This work demonstrates that CWS NCs have the potential as effective antibacterial nanozymes for the treatment of bacterial infection.
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