Fluorine in Medicinal Chemistry and Chemical Biology

Introduction Chapter 1 Unique Properties of and Their Relevance to Medicinal Chemistry and Chemical Biology by Takashi Yamazaki, Takeo Taguchi and Iwao Ojima Medicinal Chemistry Chapter 2 Prostanoids: Development of Tafluprost, a New Anti-glaucoma Agent by Yasushi Matsumura Chapter 3 conformationally restricted glutamate analogs for CNS drug discovery and development by Atsuro Nakazato Chapter 4 Inhibitors of Matrix Metalloproteinases by Roberta Sinisi, Monika Jagodzinska, Gabriele Candiani, Florent Huguenot, Monica Sani, Alessandro Volonterio, Raffaella Maffezzoni and Matteo Zanda Chapter 5 Fluoro-Taxoid Anticancer Agents by Antonella Pepe, Larisa Kuznetsova, Liang Sun and Iwao Ojima Chapter 6 Antimalarial Fluoroartemisinins: Increased Metabolic and Chemical Stabilityby Jean-Pierre Begue, Daniele Bonnet-Delpon Chapter 7 and Biological Activity of Fluorinated by Tokumi Maruyama, Masahiro Ikejiri, Kunisuke Izawa and Tomoyuki Onishi Synthetic methods for medicinal chemistry and chemical biology Chapter 8 of gem -Difluoromethylenated Nucleosides via gem -Difluoromethylene-Containing Building Blocks by Wei-Dong Meng and Feng-Ling Qing Chapter 9 Recent Advances in the Syntheses of Fluorinated Amino by Kenji Uneyama Chapter 10 Moieties for Replacement of Amide and Peptide Bonds by Takeo Taguchi and Hikaru Yanai Chapter 11 Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery by David Armstrong, Matthew W. Cartwright, Emma L. Parks, Graham Pattison, Graham Sandford, Rachel Slater, John A. Christopher, David D. Miller, Paul W. Smith and Antonio Vong Chapter 12 gem -Difluorocyclopropanes as key building blocks for novel biologically active molecules by Toshiyuki Itoh Chapter 13 Fluorous Mixture Synthesis (FMS) of Drug-Like Molecules and Enantiomers, Stereoisomers, and Analogs of Natural Products by Wei Zhang Chapter 14 Fluorine-18 Radiopharmaceuticals by Michael R. Kilbourn and Xia Shao Applications of fluorinated amino acids and peptides to chemical biology and pharmacology Chapter 15 Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins by Mario Salwiczek, Toni Vagt and Beate Koksch Chapter 16 Amino Acids and Biomolecules in Protein Design and Chemical Biology by He Meng, Ginevra A. Clark , and Krishna Kumar Chapter 17 Effects of Fluorination on the Bioorganic Properties of Methionine by John F. Honek Chapter 18 Structure analysis of membrane-active peptides using 19 F-labeled amino acids and solid state NMR by Parvesh Wadhwani and Erik Strandberg Chapter 19 Metabolism of Fluorine-containing Drugs using in vivo Magnetic Resonance Spectroscopy by Erika Schneider Appendix FDA-Approved Active Pharmaceutical Ingredients Containing Fluorine by Elizabeth Pollina-Cormier, Manisha Das, and Iwao Ojima