生物
再生(生物学)
心肌细胞
卫星
细胞生物学
史诗
肌肉损伤
神经科学
内分泌学
航空航天工程
艺术
文学类
工程类
作者
William Roman,Pura Muñoz‐Cánoves
标识
DOI:10.1016/j.tcb.2022.03.001
摘要
The incredible ability of satellite cells to regenerate muscle has captivated much of the research field's attention over the past decades. Versatile, enigmatic, vigorous, and skillful, the satellite cell is the optimal actor to cast in a regenerative epic, grabbing contracts and making headlines. However, the scenarios that play out during normal muscle usage, such as during exercise and aging, diverge from the experimental setup staged to spotlight satellite cells. Recent studies examining myofibers have highlighted novel attributes, including a capacity for self-repair. We discuss here the distinctions between myofiber self-repair and satellite-cell-dependent regeneration and how they may cooperate to repair damage after exercise, in myopathies, and in aging.
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