己内酰胺
过硫酸钾
共聚物
高分子化学
差示扫描量热法
嫁接
肿胀 的
傅里叶变换红外光谱
化学
核化学
聚合
材料科学
化学工程
有机化学
聚合物
热力学
物理
工程类
复合材料
作者
Kummara Madhusudana Rao,P. Sudhakar,K. Chowdoji Rao,M. C. S. Subha
摘要
Biodegradable sodium alginate-g-poly (vinyl caprolactam) synthesized by graft copolymerization of N-vinyl caprolactam (VCL) on to sodium alginate (NaAlg) via free radical initiation mechanism using a redox initiation system. Grafting (%), efficiency (%), and conversion (%) were all found to depend on the content of potassium persulfate (KPS), VCL reaction temperature and time. The maximum % of grafting was ascertained to be 251 at the optimum conditions of 65 o C reaction temperature, 180 min of reaction time, 1.1098X10 -3 mol of KPS and 7.1844X10 -3 mol of VCL. Evidence of graft copolymerization was obtained by fouriertransform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Further, graft copolymer was used for preparation of microgels (MGs) using Ca +2 as a crosslinking agent. SEM results showed that the MGs are spherical in structure with smooth surface. The effects of pH and temp erature on the swelling behaviour of MGs were studied and ascertained that they were sensitive to both pH and temperature. 5-FU drug was successfully loaded in to these MGs and encapsulation efficiency was found 84%. The release of 5-FU was systematically investigated as a function of temperature, pH, amount of crosslinker and % of drug loading concentration. The results indicate that the responsive MGs have the potential to be used as an effective pH and temperature controlled delivery of 5-FU for more than 12 h.
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