化学
戒指(化学)
药物化学
共轭体系
有机化学
废止
作者
Yoshihiko Ito,Shotaro Fujii,Masashi Nakatuska,Fumio Kawamoto,Takeo Saegusa
标识
DOI:10.1002/0471264180.os059.17
摘要
One-carbon ring expansion of cycloalkanones to conjugated cycloalkenones: 2-cyclohepten-1-one
intermediate: 1-trimethylsilyloxycyclohexene
reactant: 18.5 g. (0.146 mole) of diethylzinc
reactant: 40.2 g. (0.150 mole) of diiodomethane
intermediate: 1-trimethylsilyloxybicyclo[4.1.0]heptane
product: 2-cyclohepten-1-one
byproduct: 3-chlorocycloheptanone
Keywords:
annulation, carbocyclic-[3];
cleavage, oxidative;
cyclization, free radical-carbenoid/nitrenoid;
elimination, dehydrohalogenation;
diethyl ether;
N,N-dimethylformamide;
triethylamine;
diethylzinc, pyrophoric;
diethylzinc, disposal;
syringe, gas-tight
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