Aerobic exercise training reduces bronchial hyper-responsiveness and serum pro-inflammatory cytokines in patients with asthma

Commentary on: França-Pinto A, Mendes FAR, de Carvalho-Pinto RM, et al. Aerobic training decreases bronchial hyper-responsiveness and systemic inflammation in patients with moderate or severe asthma: a randomised controlled trial. Thorax 2015;70:732–9.[OpenUrl][1][Abstract/FREE Full Text][2] Exercise is a well-known trigger for asthma symptoms. In patients with asthma, strenuous physical activity increases the risk of an asthma attack, with a ‘U’-shaped curve showing that moderate exercise training carries a lower risk of asthma compared to high-intensity exercise training. Lack of physical activity appears to be independently associated with increased bronchial hyper-responsiveness (BHR).1 These observations are confirmed by a growing number of murine studies, but reviews examining the epidemiological evidence for such associations in humans show that the overall evidence on exercise and asthma is, at best, very … [1]: {openurl}?query=rft.jtitle%253DThorax%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fthoraxjnl-2014-206070%26rft_id%253Dinfo%253Apmid%252F26063507%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=thoraxjnl&resid=70/8/732&atom=%2Febmed%2F21%2F2%2F70.atom