增强子
生物
小RNA
增强子rna
遗传学
基因表达
抄写(语言学)
转录因子
非编码RNA
基因表达调控
表观遗传学
基因
细胞生物学
语言学
哲学
作者
Min Xiao,Jin Li,Li Wei,Yu Wang,Feizhen Wu,Yanping Xi,Lan Zhang,Chao Ding,Huaibing Luo,Yán Li,Lina Peng,Liping Zhao,Shaoliang Peng,Yao Xiao,Shihua Dong,Jie Cao,Wenqiang Yu
出处
期刊:RNA Biology
[Informa]
日期:2017-05-30
卷期号:14 (10): 1326-1334
被引量:260
标识
DOI:10.1080/15476286.2015.1112487
摘要
MicroRNAs (miRNAs) are small non-coding RNAs that function as negative gene expression regulators. Emerging evidence shows that, except for function in the cytoplasm, miRNAs are also present in the nucleus. However, the functional significance of nuclear miRNAs remains largely undetermined. By screening miRNA database, we have identified a subset of miRNA that functions as enhancer regulators. Here, we found a set of miRNAs show gene-activation function. We focused on miR-24-1 and found that this miRNA unconventionally activates gene transcription by targeting enhancers. Consistently, the activation was completely abolished when the enhancer sequence was deleted by TALEN. Furthermore, we found that miR-24-1 activates enhancer RNA (eRNA) expression, alters histone modification, and increases the enrichment of p300 and RNA Pol II at the enhancer locus. Our results demonstrate a novel mechanism of miRNA as an enhancer trigger.
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