Prevention Strategies for Contrast-Induced Nephropathy

Letters18 October 2016Prevention Strategies for Contrast-Induced NephropathyEric B. Bass, MD, MPH and Rathan M. Subramaniam, MD, PhD, MPHEric B. Bass, MD, MPHFrom Evidence-based Practice Center, Johns Hopkins University, and Johns Hopkins School of Medicine, Baltimore, Maryland.Search for more papers by this author and Rathan M. Subramaniam, MD, PhD, MPHFrom Evidence-based Practice Center, Johns Hopkins University, and Johns Hopkins School of Medicine, Baltimore, Maryland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0278 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Cain and Ms. Goldstone's concern about the possibility of falsely low serum creatinine measurements in the presence of NAC when the Trinder and Trinder-like reaction assays are used. When we reviewed Genzen and associates' study (1), we found that low doses of NAC did not substantially affect the serum creatinine level. Thus, we see no reason to change our conclusion that low strength of evidence indicates that low-dose NAC plus intravenous saline compared with intravenous saline had a clinically important benefit.The concern then mainly applies to studies using high doses of NAC. Many of ...Reference1. Genzen JR, Hunsaker JJ, Nelson LS, Faine BA, Krasowski MD. N-acetylcysteine interference of Trinder-based assays. Clin Biochem. 2016;49:100-4. [PMID: 26500003] doi:10.1016/j.clinbiochem.2015.10.005 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Evidence-based Practice Center, Johns Hopkins University, and Johns Hopkins School of Medicine, Baltimore, Maryland.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-1456. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffectiveness of Prevention Strategies for Contrast-Induced Nephropathy Rathan M. Subramaniam , Catalina Suarez-Cuervo , Renee F. Wilson , Sharon Turban , Allen Zhang , Cheryl Sherrod , Jonathan Aboagye , John Eng , Michael J. Choi , Susan Hutfless , and Eric B. Bass Prevention Strategies for Contrast-Induced Nephropathy James Cain and Jamie Goldstone Metrics Cited byNursing diagnoses of patients with kidney disease undergoing hemodialysis: a cross-sectional studyRelaxin Attenuates Contrast-Induced Human Proximal Tubular Epithelial Cell Apoptosis by Activation of the PI3K/Akt Signaling Pathway In Vitro 18 October 2016Volume 165, Issue 8Page: 601KeywordsCreatinineDisclosure ePublished: 18 October 2016 Issue Published: 18 October 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...