布地奈德
超临界流体
悬挂(拓扑)
生物利用度
肺表面活性物质
色谱法
干粉吸入器
药物输送
材料科学
剂型
沉积(地质)
化学
生物医学工程
药理学
吸入
纳米技术
医学
吸入器
麻醉
有机化学
数学
哮喘
内科学
生物
古生物学
生物化学
同伦
沉积物
纯数学
作者
Amir Amani,Henry Chrystyn,Brian J. Clark,Mohamed Abdelrahim,Peter York
标识
DOI:10.1211/jpp/61.12.0006
摘要
Currently, suspensions prepared from micronised drug substances are the only delivery system marketed for nebulisation of steroids, and reported inconsistent or low bioavailability arising from their use provides a rationale for researching alternative formulations. Supercritical fluid processing of drug substances to obtain respirable-sized particles has been used over the last decade to formulate dry powder inhalers. We aimed thus to process budesonide powder to improve its deposition characteristics.In an attempt to overcome the limitations of nebuliser suspensions when prepared from micronised drug particles, budesonide powder was processed using a supercritical fluid based process and suspended using Tween 80 as a surfactant to provide an aqueous nebuliser formulation. The in-vitro characteristics of the emitted dose on nebulisation for the prepared suspension were then compared to a commercially available suspension formulation of budesonide using a jet and a vibrating mesh nebuliser.The results showed a significant improvement of the in-vitro deposition properties of the suspension containing supercritical fluid engineered budesonide particles.The results indicated the benefit of such materials compared with traditionally micronised drug powders.
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