降钙素基因相关肽
音猬因子
牙槽
降钙素
刺猬信号通路
神经肽
内科学
细胞生物学
生物
内分泌学
信号转导
医学
受体
牙科
作者
Pai Pang,Tsuyoshi Shimo,Hiroyuki Takada,K. Matsumoto,Norie Yoshioka,Soichiro Ibaragi,Akira Sasaki
标识
DOI:10.1016/j.bbrc.2015.09.139
摘要
Sonic Hedgehog (SHH), a neural development inducer, plays a significant role in the bone healing process. Calcitonin gene-related peptide (CGRP), a neuropeptide marker of sensory nerves, has been demonstrated to affect bone formation. The roles of SHH signaling and CGRP-positive sensory nerves in the alveolar bone formation process have been unknown. Here we examined the expression patterns of SHH signaling and CGRP in mouse socket by immunohistochemistry and immunofluorescence analysis. We found that the expression level of SHH peaked at day 3 and was then decreased at 5 days after tooth extraction. CGRP, PTCH1 and GLI2 were each expressed in a similar pattern with their highest expression levels at day 5 and day 7 after tooth extraction. CGRP and GLI2 were co-expressed in some inflammatory cells and bone forming cells. In some areas, CGRP-positive neurons expressed GLI2. In conclusion, SHH may affect alveolar bone healing by interacting with CGRP-positive sensory neurons and thus regulate the socket's healing process after tooth extraction.
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