Local recurrence and other oncologic outcomes after percutaneous image-guided tumor ablations on stageT1b renal cell carcinoma: a systematic review and network meta-analysis

医学 低温消融 肾细胞癌 微波消融 经皮 临床终点 不利影响 肾癌 射频消融术 烧蚀 荟萃分析 临床试验 外科 随机对照试验 放射科 肿瘤科 内科学
作者
Grégoire Cazalas,E. Jambon,Alexis Coussy,Yann Le Bras,François Petitpierre,Jean Christophe Berhnard,Nicolas Grenier,C. Marcelin
出处
期刊:International Journal of Hyperthermia [Taylor & Francis]
卷期号:38 (1): 1295-1303 被引量:3
标识
DOI:10.1080/02656736.2021.1970826
摘要

Objective A systematic review of clinical trials on thermal ablation of T1b RCC was conducted to assess oncologic outcomes of those procedures. The primary endpoint was the rate of local recurrence. Secondary endpoints included technical efficacy, progression to metastatic disease, cancer-specific mortality, complications and renal function decrease. Methods PubMed (MEDLINE) and Embase databases were searched in June 2020 for eligible trials following the PRISMA selection process. Prevalence of local recurrence and per procedural major adverse effects were calculated using double arcsine transformation and a random-effects model. Results Nine clinical trials (all retrospective) involving 288 patients with T1b renal clear cell carcinoma treated with either percutaneous microwave ablation, cryoablation or radiofrequency ablation were analyzed. Using a random-effects model, the overall prevalence of local recurrence following percutaneous ablation was 0.08 (0.04-0.14; p = 0.05). Primary technical efficacy was 226/263 (86%) patients and secondary technical efficacy was 247/263 (94%). Overall, 10/176 (6%) patients presented metastatic locations following the ablation. Major adverse effects prevalence was 0.09 (0.06-0.14; p = 0.05). Conclusions Thermal ablations are feasible, safe, and effective to treat T1b renal clear cell carcinoma. More trials are necessary to determine the rate of the evidence of the benefit.HighlightsThermal ablations are feasible and safe to treat T1b renal clear cell carcinoma.Oncologic outcomes appear to be very good on both local control and distant progression.Due to small number and heterogeneity of studies more trials are necessary to determine the rate of the evidence of the benefit.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
luan完成签到,获得积分10
刚刚
婷婷发布了新的文献求助10
刚刚
熹熹完成签到,获得积分10
2秒前
supertkeb应助阳光的卿采纳,获得10
3秒前
meini发布了新的文献求助10
3秒前
小马想毕业完成签到,获得积分10
3秒前
ZhiningZ完成签到 ,获得积分10
4秒前
科研牛马完成签到,获得积分10
5秒前
科研通AI5应助科研通管家采纳,获得10
7秒前
情怀应助科研通管家采纳,获得10
7秒前
隐形曼青应助科研通管家采纳,获得10
7秒前
Ava应助科研通管家采纳,获得10
7秒前
大模型应助科研通管家采纳,获得100
7秒前
汉堡包应助科研通管家采纳,获得10
7秒前
科研通AI5应助科研通管家采纳,获得10
7秒前
Auston_zhong应助科研通管家采纳,获得10
7秒前
星辰大海应助科研通管家采纳,获得10
8秒前
Jasper应助科研通管家采纳,获得10
8秒前
8秒前
10秒前
10秒前
外向的妍完成签到,获得积分10
13秒前
13秒前
殷勤的紫槐发布了新的文献求助200
13秒前
天麟发布了新的文献求助10
13秒前
乐乐应助Lll采纳,获得10
14秒前
Wang发布了新的文献求助10
15秒前
17秒前
中科路2020完成签到,获得积分10
18秒前
缥缈的绿兰完成签到,获得积分10
19秒前
19秒前
陌上花开完成签到,获得积分20
21秒前
菜热热完成签到,获得积分10
22秒前
Lll完成签到,获得积分20
23秒前
陌上花开发布了新的文献求助10
23秒前
Catherine_Song完成签到 ,获得积分10
24秒前
司忆完成签到 ,获得积分10
25秒前
外向的沛柔完成签到,获得积分20
25秒前
猴子发布了新的文献求助10
25秒前
研友_GZbV4Z完成签到,获得积分10
27秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Production Logging: Theoretical and Interpretive Elements 3000
CRC Handbook of Chemistry and Physics 104th edition 1000
Izeltabart tapatansine - AdisInsight 600
Introduction to Comparative Public Administration Administrative Systems and Reforms in Europe, Third Edition 3rd edition 500
Distinct Aggregation Behaviors and Rheological Responses of Two Terminally Functionalized Polyisoprenes with Different Quadruple Hydrogen Bonding Motifs 450
Individualized positive end-expiratory pressure in laparoscopic surgery: a randomized controlled trial 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3761774
求助须知:如何正确求助?哪些是违规求助? 3305540
关于积分的说明 10134658
捐赠科研通 3019564
什么是DOI,文献DOI怎么找? 1658226
邀请新用户注册赠送积分活动 791989
科研通“疑难数据库(出版商)”最低求助积分说明 754751