肝星状细胞
缬氨酸
亮氨酸
肝细胞生长因子
异亮氨酸
分泌物
肝细胞
内分泌学
内科学
氨基酸
化学
克隆(Java方法)
肝细胞学
生物
细胞培养
生物化学
体外
受体
基因
医学
肝脏代谢
遗传学
作者
Tomoaki Tomiya,Yukiko Inoue,Mikio Yanase,Masahiro Arai,Hitoshi Ikeda,Kazuaki Tejima,Kōzō Nagashima,Tatsuya Nishikawa,Kenji Fujiwara
标识
DOI:10.1016/s0006-291x(02)02339-2
摘要
Branched-chain amino acids (BCAAs) modulate various cellular functions, in addition to providing substrates for the production of proteins. In this study, we examined the effect of BCAAs on the secretion of hepatocyte growth factor (HGF) by hepatic stellate cells. A hepatic stellate cell clone was cultured in medium supplemented with various concentrations of valine, leucine, or isoleucine. Of these BCAAs, leucine markedly induced an increase in the levels of HGF in the medium in a dose-dependent manner. The addition of valine or isoleucine had no significant effect on HGF levels in the medium. The difference in levels of HGF in the medium between leucine-treated and non-treated cells was enhanced by the incubation period. These results demonstrate that, among BCAAs, leucine stimulates the secretion of HGF by cultured hepatic stellate cells.
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