旁分泌信号
肿瘤微环境
前列腺癌
自分泌信号
癌症
生物
基质
神经科学
癌细胞
癌症研究
细胞外基质
癌变
病理
医学
细胞生物学
免疫学
肿瘤细胞
细胞培养
免疫组织化学
受体
生物化学
遗传学
作者
Aleksandra Sejda,Dawid Sigorski,Jacek Gulczyński,Wojciech Wesołowski,Joanna Kitlińska,Ewa Iżycka‐Świeszewska
出处
期刊:Pathobiology
[S. Karger AG]
日期:2020-01-01
卷期号:87 (2): 87-99
被引量:26
摘要
The tumor microenvironment (TME) plays an essential role in the development and progression of neoplasms. TME consists of the extracellular matrix and numerous specialized cells interacting with cancer cells by paracrine and autocrine mechanisms. Tumor axonogenesis and neoneurogenesis constitute a developing area of investigation. Prostate cancer (PC) is one of the most common malignancies in men worldwide. During the past years, more and more studies have shown that mechanisms leading to the development of PC are not confined only to the epithelial cancer cell, but also involve the tumor stroma. Different nerve types and neurotransmitters present within the TME are thought to be important factors in PC biology. Moreover, perineural invasion, which is a common way of PC spreading, in parallel creates the neural niche for malignant cells. Cancer neurobiology seems to have become a new discipline to explore the contribution of neoplastic cell interactions with the nervous system and the neural TME component, also to search for potential therapeutic targets in malignant tumors such as PC.
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