肠道菌群
拟杆菌
胆固醇
益生元
粪便
新陈代谢
双歧杆菌
果胶
还原酶
生物化学
化学
乳酸菌
食品科学
短链脂肪酸
低密度脂蛋白
生物
细菌
微生物学
酶
发酵
丁酸盐
遗传学
作者
Haijuan Hu,Shanshan Zhang,Fengxia Liu,Peipei Zhang,Muhammad Zafarullah,Siyi Pan
标识
DOI:10.1021/acs.jafc.9b03731
摘要
We investigated the regulatory effects of citrus pectin oligosaccharides (POS) from an innovative, chemically controllable degradation process on cholesterol metabolism and the gut microbial composition. The modulatory role of the intestinal flora was explored. Four-week-old male C57BL/6 mice were fed either a standard diet; a high-fat (HF) diet; or a HF diet with 0.15, 0.45, and 0.9 g/kg body weight POS for 30 days. POS reduced serum total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) in a dose-dependent manner. The relative abundances of specific bacterial groups in the feces and the concentrations of their metabolites were higher in the POS groups. There were significant correlations among Bifidobacterium, Lactobacillus, and Bacteroides and short-chain fatty acids, as well as among serum TC, LDL-C, fecal bile acids, and liver cholesterol 7-α-hydroxylase and 3-hydroxy-3-methylglutaryl-coenzyme A reductase. These findings indicate that the prepared POS exhibited hypocholesterolemic effects and that the potential regulatory mechanisms of citrus POS on cholesterol metabolism are modulated by specific bacterial groups together with their metabolites.
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