医学
非酒精性脂肪肝
内科学
胰岛素抵抗
荟萃分析
随机对照试验
脂肪肝
体质指数
血脂谱
丙氨酸转氨酶
胃肠病学
物理疗法
疾病
胰岛素
胆固醇
作者
Heechul Nam,Jeong‐Ju Yoo,Yuri Cho,Seong Hee Kang,Sang Bong Ahn,Hye Won Lee,Dae Won Jun,Do Seon Song,Miyoung Choi
标识
DOI:10.1016/j.dld.2022.12.013
摘要
The global burden of nonalcoholic fatty liver disease (NAFLD) is rapidly increasing.This study aimed to evaluate the effect of exercise on intrahepatic lipid (IHL), serum alanine aminotransferase (ALT), body mass index (BMI), and insulin resistance in NAFLD patients.We searched MEDLINE, Embase, Cochrane CENTRAL, KMbase, and the Korean Studies Information Service System through April 2022. The included studies were randomised control trials (RCTs) of exercise, in which IHL was measured using magnetic resonance imaging in adult NAFLD patients.Eleven RCTs with 577 participants were included in this meta-analysis. Exercise was significantly associated with a reduction in IHL (mean difference (MD), -2.03; 95% CI, -3.26 to -0.79; P = 0.001) and a decrease in ALT (MD, -4.17; 95% CI, -6.60 to -1.73; P = 0.0008). Regarding the duration of exercise, maintaining exercise for more than 3 months significantly improved IHL (MD, -3.62; 95% CI, -5.76 to -1.48; P = 0.0009), while exercise for less than 3 months did not (MD, -1.23; 95% CI, -2.74 to 0.29; P = 0.11). BMI and insulin resistance did not improve significantly with exercise.We found that exercise improved IHL and ALT levels in NAFLD patients. The effect of exercise is particularly increased when one engages in exercises that last longer than 3 months.
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