缺氧(环境)
转移
平衡
信号转导
肿瘤进展
癌症研究
肿瘤缺氧
表型
肿瘤微环境
生物
癌症
医学
肿瘤细胞
内科学
细胞生物学
化学
氧气
放射治疗
生物化学
有机化学
基因
作者
Luana Schito,Sergio Rey-Keim
标识
DOI:10.1016/j.semcancer.2023.11.001
摘要
Disruption of oxygen homeostasis, resulting from an imbalance between O2 supply and demand during malignant proliferation, leads to the development of hypoxic tumor microenvironments that promote the acquisition of aggressive cancer cell phenotypes linked to metastasis and patient mortality. In this review, the mechanistic links between tumor hypoxia and metastatic progression are presented. Current status and perspectives of targeting hypoxia signaling pathways as a strategy to halt cancer cell metastatic activities are emphasized.
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