突触可塑性
生物
细胞生物学
神经科学
信号转导
神经传递
神经系统
受体
生物化学
作者
Mengting Wu,Huihui Jiang,Qian Li,Yunhe Liu,Hongjun Zhang,Xuekun Li,Zhiyong Shao
摘要
Abstract The formation and maintenance of synapses are precisely regulated, and the misregulation often leads to neurodevelopmental or neurodegenerative disorders. Besides intrinsic genetically encoded signaling pathways, synaptic structure and function are also regulated by extrinsic factors, such as nutrients. O‐GlcNAc transferase (OGT), a nutrient sensor, is abundant in the nervous system and required for synaptic plasticity, learning, and memory. However, whether OGT is involved in synaptic development and the mechanism underlying the process are largely unknown. In this study, we found that OGT‐1, the OGT homolog in C. elegans , regulates the presynaptic assembly in AIY interneurons. The insulin receptor DAF‐2 acts upstream of OGT‐1 to promote the presynaptic assembly by positively regulating the expression of ogt‐1 . This insulin‐OGT‐1 axis functions most likely by regulating neuronal activity. In this study, we elucidated a novel mechanism for synaptic development, and provided a potential link between synaptic development and insulin‐related neurological disorders.
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