化学
亲核细胞
四级碳
铜
催化作用
第四纪
碳纤维
戒指(化学)
联轴节(管道)
组合化学
有机化学
对映选择合成
古生物学
地质学
机械工程
材料科学
复合数
工程类
复合材料
作者
Bin Li,Jingyuan Shi,Ying Xia
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-04-11
卷期号:25 (15): 2674-2679
被引量:5
标识
DOI:10.1021/acs.orglett.3c00751
摘要
The construction of all-carbon quaternary centers in small-ring systems is important but challenging in organic synthesis. Herein, by taking gem-difluorocyclopropyl bromides (DFCBs) as a type of general and versatile building block, we developed a practical method for building all-carbon quaternary centers in gem-difluorinated cyclopropanes (DFCs). The reaction relies on the involvement of a gem-difluorocyclopropyl radical intermediate, which can couple with a wide range of nucleophiles under copper catalysis.
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