Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection

免疫衰老 生物 CD8型 衰老 免疫学 2019年冠状病毒病(COVID-19) 疾病 免疫系统 内科学 医学 传染病(医学专业) 遗传学
作者
Rodrigo Pedroso,Lícia Torres,Lucas Araújo Ventura,Giovanna Caliman Camatta,Catarina Pinheiro Mota,Ana Catarina Mendes,Filipa Ribeiro,Henrique Cerqueira Guimarães,Rafael Calvão Barbuto,Felipe Caixeta,Leandro Souza Nascimento,Mariana de Almeida Oliveira,Vinícius Dantas Martins,Gabriela Silveira‐Nunes,Unaí Tupinambás,Andréa Teixeira‐Carvalho,Luís Graça,Ana Maria Caetano Faria
出处
期刊:Journal of Leukocyte Biology [Oxford University Press]
被引量:2
标识
DOI:10.1093/jleuko/qiae180
摘要

Abstract Risk factors for the development of severe COVID-19 include several comorbidities, but age was the most striking one since elderly people were disproportionately affected by SARS-CoV-2 infection. Among the reasons for this markedly unfavorable response in the elderly, immunosenescence and inflammaging appear as major drivers of this outcome. A finding that was also notable was that hospitalized patients with severe COVID-19 have an accumulation of senescent T cells, suggesting that immunosenescence may be aggravated by SARS-CoV-2 infection. The present work was designed to examine whether these immunosenescence changes are characteristic of COVID-19 and whether it is dependent on disease severity using cross-sectional and longitudinal studies. Our cross-sectional data show that COVID-19, but not other respiratory infections, rapidly increased cellular senescence and exhaustion in CD4 and CD8 T cells during early infection. In addition, longitudinal analyses with patients from Brazil and Portugal provided evidence of increased frequencies of senescent and exhausted T cells over a 7-d period in patients with mild/moderate and severe COVID-19. Altogether, the study suggests that accelerated immunosenescence in CD4 and especially CD8 T-cell compartments may represent a common and unique outcome of SARS-CoV2 infection.

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