作者
Veronica Balatti,Giovanni Nigita,Dario Veneziano,Alessandra Drusco,Gary S. Stein,Terri L. Messier,Nicholas H. Farina,Jane B. Lian,Luisa Tomasello,Chang Gong Liu,Alexey Palamarchuk,Jonathan R. Hart,Catherine Bell,Mariantonia Carosi,Edoardo Pescarmona,Letizia Perracchio,Maria Grazia Diodoro,Andrea Russo,Anna Antenucci,P. Visca,Antonio Ciardi,Curtis C. Harris,Peter K. Vogt,Yuri Pekarsky,Carlo M. Croce
摘要
Significance We found that tRNA-derived small RNAs (tsRNAs) are dysregulated in many cancers and that their expression is modulated during cancer development and staging. Indeed, activation of oncogenes and inactivation of tumor suppressors lead to a dysregulation of specific tsRNAs, and tsRNA-KO cells display a specific change in gene-expression profile. Thus tsRNAs could be key effectors in cancer-related pathways. These results indicate active crosstalk between tsRNAs and oncogenes and suggest that tsRNAs could be useful markers for diagnosis or targets for therapy. Additionally, ts-46 and ts-47 affect cell growth in lung cancer cell lines, further confirming the involvement of tsRNAs in cancer pathogenesis.