The Dual Face of Cyclin B1

Although widely used as a marker for cell proliferation, CYCB1;1 expression is also strongly induced in cells that suffer from DNA damage. Recently, this enigmatic dual expression pattern has been resolved by proving that CYCB1;1 promotes DNA repair. This has consequences for using CYCB1;1 as a cell cycle reporter. Although widely used as a marker for cell proliferation, CYCB1;1 expression is also strongly induced in cells that suffer from DNA damage. Recently, this enigmatic dual expression pattern has been resolved by proving that CYCB1;1 promotes DNA repair. This has consequences for using CYCB1;1 as a cell cycle reporter.