丝胶
胶束
阿霉素
生物物理学
材料科学
药品
毒品携带者
药物输送
两亲性
化学
药理学
共聚物
聚合物
纳米技术
有机化学
医学
化疗
生物
丝绸
外科
水溶液
复合材料
作者
Weihong Guo,Lei Deng,Jiang Yu,Zhaoyu Chen,Yanghee Woo,Hao Líu,Tuanjie Li,Tian Lin,Hao Chen,Mingli Zhao,Liming Zhang,Guoxin Li,Yanfeng Hu
出处
期刊:Drug Delivery
[Informa]
日期:2018-01-01
卷期号:25 (1): 1103-1116
被引量:45
标识
DOI:10.1080/10717544.2018.1469686
摘要
Drug resistance is the major challenge facing cancer chemotherapy and nanoscale delivery systems based on natural materials, such as sericin, are a promising means of overcoming drug resistance. Yet, no attempt of introducing synthetic poly(γ-benzyl-L-glutamate) (PBLG) onto sericin polypeptide to fabricate a facile biocompatible and biodegradable micelle has been tried. Here, we prepared a polypeptide-based amphiphilic polymer containing hydrophilic sericin polypeptide backbone and PBLG side chains via ring-opening polymerization (ROP) strategy. The introduction of PBLG side chains remarkably enhances the stability of sericin micelles in water. Meanwhile, the micelles exhibited a high loading capacity and pH-responsive release ability for antitumor drug doxorubicin (DOX), called sericin-PBLG-DOX. Owing to the excellent cell membrane penetration of sericin-PBLG, the cellular uptake of DOX when loaded into micelles was improved. Subsequently, sericin-PBLG-DOX was transferred into perinuclear lysosomes, where the release rate of DOX was accelerated. Compared to the same dose of DOX, sericin-PBLG-DOX could induce a more efficient anti-tumor effect both in vitro and in vivo, and these micelles have promise for future clinical applications in overcoming cancer drug resistance with good biosafety, enhanced cellular uptake, pH-triggered drug release, efficient anti-tumor effects, and minimized systemic toxicity.
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