吲哚青绿
费斯特共振能量转移
纳米团簇
材料科学
光热治疗
荧光
光敏剂
荧光寿命成像显微镜
光动力疗法
光热效应
纳米技术
光化学
化学
光学
物理
有机化学
作者
Haodong Cui,Dehong Hu,Jingnan Zhang,Guanhui Gao,Ze Chen,Wenjun Li,Ping Gong,Zonghai Sheng,Lintao Cai
标识
DOI:10.1021/acsami.7b06192
摘要
Well-designed gold nanoclusters-indocyanine green nanoprobes (Au NCs-INPs) have been developed by the conjugation of Au NC assemblies with indocyanine green (ICG) for the therapeutic real-time monitoring based on fluorescence resonance energy transfer (FRET). The synthesized Au NCs-INPs demonstrated the improved cellular uptake and effective tumor targeting because of the enhanced permeability and retention effect and the gp60-mediated secreted protein acidic and rich in cysteine combined transport pathway, suggesting excellent dual-modal near-infrared fluorescence and photoacoustic imaging. Moreover, the simultaneous photodynamic therapy (PDT) and photothermal therapy (PTT) of Au NCs-INPs exhibited higher cancer cell killing and tumor removal efficiency than those of PDT or PTT alone. More importantly, a promising therapeutic monitoring strategy was performed based on FRET between Au NCs and ICG, suggesting that Au NCs-INPs could be utilized to evaluate the therapeutic response by real-time monitoring the change in Au NCs in fluorescence intensity together with ICG supersession. Therefore, Au NCs-INPs as a novel photosensitizer have great potentials for combined tumor imaging, therapy, and therapeutic monitoring in real time.
科研通智能强力驱动
Strongly Powered by AbleSci AI