立体中心
吡那考
硼酸化
化学
烷基
产量(工程)
烯丙基重排
硼酸
组合化学
立体化学
有机化学
对映选择合成
芳基
催化作用
冶金
材料科学
作者
Phillip J. Unsworth,Daniele Leonori,Varinder K. Aggarwal
标识
DOI:10.1002/anie.201405700
摘要
Three more: The 3C homologation of chiral pinacol boronic esters gives di- or trisubstituted allylic boronic esters with high yield and E selectivities. The combination of this method with lithiation–borylation enables the synthesis of alkyl chains that bear 1,5-stereogenic centers. The utility of the process was demonstrated in a formal synthesis of (+)-jasplakinolide.
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