PTEN公司
罗格列酮
细胞凋亡
癌症研究
结直肠癌
细胞周期
细胞毒性T细胞
化学
癌症
癌细胞
生物
细胞生物学
医学
内科学
受体
体外
PI3K/AKT/mTOR通路
生物化学
作者
Jarmila Lauková,Alois Kozubı́k,Jiřina Hofmanová,Jana Nekvindová,Petr Sova,Mary Pat Moyer,Jiří Ehrmann,Alena Hyršlová Vaculová
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2015-10-22
卷期号:10 (10): e0141020-e0141020
被引量:5
标识
DOI:10.1371/journal.pone.0141020
摘要
We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on p53 and PPARγ proteins, and accompanied with significant changes of selected Bcl-2 family protein levels. Further stimulation of cooperative synergic cytotoxic action of rosiglitazone and LA-12 was demonstrated in the cells deficient for PTEN, where mitochondrial apoptotic pathway was more stimulated and G1-phase-associated dying was reinforced. Our results suggest that combined treatment with rosiglitazone and LA-12 might be promising anticancer strategy in colon-derived tumours regardless of their p53 status, and also favourable in those defective in PTEN function.
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