硬脂酸
溶血
多糖
脂肪酸
胶束
化学
嫁接
体外
有机化学
生物化学
水溶液
生物
免疫学
聚合物
作者
Wenping Wang,Shaolong He,Tongtong Hong,Yumei Zhang,Hong Sui,Xia Zhang,Yan Ma
标识
DOI:10.3109/21691401.2015.1129621
摘要
Hydrophobic modification of Bletilla striata polysaccharide (BSP) was performed by grafting fatty acids to BSP backbone and then characterized on their physicochemical properties. All neutral derivatives were able to self-assemble into spherical particles within the size range of 250–400 nm, their size and critical micelle concentration decreased with increasing hydrophobicity and substitution degree of the fatty acids. Also, the BSP-stearic acid conjugates showed a preferable performance on hemolysis test and cytotoxicity analysis on HepG2 cells, which suggested their potential application as a drug delivery vector.
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