活性氧
氧化应激
过氧化氢
抗氧化剂
化学
细胞生物学
氧化磷酸化
炎症
生物化学
生物
免疫学
作者
Kye S Kim,Dongwon Lee,Chul-Gyu Song,Peter M. Kang
出处
期刊:Nanomedicine
日期:2015-09-01
卷期号:10 (17): 2709-2723
被引量:68
摘要
Reactive oxygen species (ROS) are generated from the endogenous oxidative metabolism or from exogenous pro-oxidant exposure. Oxidative stress occurs when there is excessive production of ROS, outweighing the antioxidant defense mechanisms which may lead to disease states. Hydrogen peroxide (H2O2) is one of the most abundant and stable forms of ROS, implicated in inflammation, cellular dysfunction and apoptosis, which ultimately lead to tissue and organ damage. This review is an overview of the role of ROS in different diseases. We will also examine ROS-activated nanomaterials with emphasis on hydrogen peroxide, and their potential medical implications. Further development of the biocompatible, stimuli-activated agent responding to disease causing oxidative stress, may lead to a promising clinical use.
科研通智能强力驱动
Strongly Powered by AbleSci AI