When to consider logistic LASSO regression in multivariate analysis?

We read with great interests the study by Dr. Bonvalot et al. [ [1] Bonvalot S. Wunder J. Gronchi A. et al. Complete pathological response to neoadjuvant treatment is associated with better survival outcomes in patients with soft tissue sarcoma: results of a retrospective multicenter study. Eur J Surg Oncol. 2021; https://doi.org/10.1016/j.ejso.2021.02.024 Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar ] In this retrospective observational study of 330 patients treated with neoadjuvant treatment and surgical resection for soft tissue sarcoma, multivariate analysis showed that pathological complete response (pCR) to neoadjuvant treatment was independently associated with better distant recurrence-free survival (MFS), local recurrence-free survival (LRFS), disease-free survival (DFS) and overall survival (OS) at 3 years. Though inspiring, several points about the statistical analysis of this study warrants further elucidation. Reply to “When to consider logistic LASSO regression in multivariate analysis?”European Journal of Surgical OncologyVol. 47Issue 8PreviewWe thank Dr Jia-Yu Hu and colleagues, Ying Wang, Xiang-Min Tong, Tian Yang for their comments on our Article [1]. Below we provide short answers to the remarks posed by them. Full-Text PDF