多形性(细胞学)
病理
组织学
腺癌
免疫组织化学
腮腺
细胞病理学
人口
细胞学
增殖指数
医学
生物
癌症
内科学
环境卫生
作者
Gideon Ze Lin Tan,Giap Hean Goh,Kwok Seng Loh,Fredrik Petersson
标识
DOI:10.1016/j.anndiagpath.2021.151806
摘要
We present a case of a 1.0 cm primary tumor of the left parotid gland that meets the histological criteria for the recently described entity sclerosing microcystic adenocarcinoma. The patient was a 73-year-old man with a concurrent tonsillar squamous cell carcinoma, and a history of nasopharyngeal carcinoma treated with radiotherapy 23 years prior. Fine needle aspiration cytology demonstrated low-grade biphasic basaloid neoplastic cells arranged in branching sheets and clusters with minimal nuclear pleomorphism. A biphasic appearance was apparent and some of the cell clusters were bordered by a layer of flattened cells with ovoid bland nuclei. On histology, the tumor comprised small bilayered infiltrative tubules, nests, cords, and microcysts. On immunohistochemistry, EMA, SOX-10, P63, and S-100 protein highlighted a dual cell population of luminal and abluminal cells. The cells were negative for CD117, and the Ki-67 proliferation index was low (<5%).
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