姜黄素
化学
神经保护
炎症
超氧化物歧化酶
缺血
药理学
过氧化氢酶
再灌注损伤
抗氧化剂
医学
生物化学
免疫学
内科学
作者
Xiaotong Ma,Haiqiang Jin,Yingying Ren,Zhiyuan Shen,Li Wang,Shitong Zhang,Yuxuan Lu,Shanyue Guan,Shuyun Zhou,Xiaozhong Qu
标识
DOI:10.1016/j.cej.2022.136029
摘要
For alleviating ischemic reperfusion injury, reasonable design mimic multi-functional nanozyme can simultaneously capture ROS and inhibit inflammatory factors, which plays an important role. However, the low efficiency of natural enzyme and their ability to capture only a single species limit their effectiveness. Therefore, additional materials to capture other ROS are highly needed. These motivates us to construct a nanozyme via hybridize/coupled curcumin (CUR) with ZnCe Layered Rare-earth Hydroxide (ZnCe-LRH) to achieve highly efficient ROS scavenging efficiency and the multiple ROS capture (denoted as CUR/ZnCe-LRH). Ce element was highly dispersed on the LRH layer, and CUR further coordinated with Zn on the layer to form a stable nanozyme structure. This mimic tripartite nanozyme can not only simulate superoxide dismutase (SOD) and catalase (CAT) activity to capture •O2− and H2O2, but also arrest •OH within a short period of time, which can be regarded as the tripartite nanozyme. Density functional theory (DFT) calculations can further confirm the high efficient ROS scavenging mechanism by the CUR/ZnCe-LRH systems. In vivo results can further probe that this CUR/ZnCe-LRH can also suppress inflammation- and immune response–induced injury, thus achieving good prevention and treatment in neuroprotective therapy. The infarct area can reduce by 78% after the reperfusion therapy and the neurological deficit score can reduce from 3.50 to 0.67. This strategy provided a novel multifunctional enzyme mimetic for ischemia–reperfusion therapy and clarifies the application mechanism of neuroprotection against ischemia–reperfusion injury.
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