基因沉默
RNA诱导沉默复合物
RNA干扰
基因
RNA沉默
核糖核酸
遗传学
生物
G-四倍体
细胞生物学
计算生物学
DNA
标识
DOI:10.1016/j.tibs.2024.01.009
摘要
Abstract
Poly(UG) or ‘pUG' dinucleotide repeats direct gene silencing in Caenorhabditis elegans by adopting an unusual quadruplex structure. Humans have thousands of pUG sequences and proteins that interact with them. The pUG fold reveals new aspects of gene regulation and RNA folding, highlighting how a simple sequence can encode a complex structure.
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