去市场化
离解的
心理学
神经认知
默认模式网络
后扣带
人格解体
临床心理学
神经科学
内科学
功能磁共振成像
认知
医学
情绪衰竭
倦怠
作者
Erika J. Wolf,Sage E. Hawn,Danielle R. Sullivan,Mark W. Miller,Victoria Sanborn,Emma Brown,Zoë Neale,Dana Fein‐Schaffer,Xiang Zhao,Mark W. Logue,Catherine B. Fortier,Regina E. McGlinchey,William Milberg
出处
期刊:Journal of psychopathology and clinical science
[American Psychological Association]
日期:2023-05-01
卷期号:132 (4): 409-427
被引量:3
摘要
Approximately 10%-30% of individuals with posttraumatic stress disorder (PTSD) exhibit a dissociative subtype of the condition defined by symptoms of depersonalization and derealization. This study examined the psychometric evidence for the dissociative subtype of PTSD in a sample of young, primarily male post-9/11-era Veterans (n = 374 at baseline and n = 163 at follow-up) and evaluated its biological correlates with respect to resting state functional connectivity (default mode network [DMN]; n = 275), brain morphology (hippocampal subfield volume and cortical thickness; n = 280), neurocognitive functioning (n = 337), and genetic variation (n = 193). Multivariate analyses of PTSD and dissociation items suggested a class structure was superior to dimensional and hybrid ones, with 7.5% of the sample comprising the dissociative class; this group showed stability over 1.5 years. Covarying for age, sex, and PTSD severity, linear regression models revealed that derealization/depersonalization severity was associated with: decreased DMN connectivity between bilateral posterior cingulate cortex and right isthmus (p = .015; adjusted-p [padj] = .097); increased bilateral whole hippocampal, hippocampal head, and molecular layer head volume (p = .010-.034; padj = .032-.053); worse self-monitoring (p = .018; padj = .079); and a candidate genetic variant (rs263232) in the adenylyl cyclase 8 gene (p = .026), previously associated with dissociation. Results converged on biological structures and systems implicated in sensory integration, the neural representation of spatial awareness, and stress-related spatial learning and memory, suggesting possible mechanisms underlying the dissociative subtype of PTSD. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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